Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

Recent genome analyses have identified recurrent mutations in the cohesin complex in a wide range of human cancers. Here we demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction with its paralog STAG1. Mechanistically, STAG...

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Detalles Bibliográficos
Autores principales: van der Lelij, Petra, Lieb, Simone, Jude, Julian, Wutz, Gordana, Santos, Catarina P, Falkenberg, Katrina, Schlattl, Andreas, Ban, Jozef, Schwentner, Raphaela, Hoffmann, Thomas, Kovar, Heinrich, Real, Francisco X, Waldman, Todd, Pearson, Mark A, Kraut, Norbert, Peters, Jan-Michael, Zuber, Johannes, Petronczki, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531830/
https://www.ncbi.nlm.nih.gov/pubmed/28691904
http://dx.doi.org/10.7554/eLife.26980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531830/
https://www.ncbi.nlm.nih.gov/pubmed/28691904
http://dx.doi.org/10.7554/eLife.26980

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