Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model

A series of phthalimide analogues, novelized with high-valued bioactive scaffolds was synthesized by means of click-chemistry under non-conventional microwave heating and evaluated as noteworthy growth inhibitors of Plasmodium falciparum (3D7 and W2) in culture. Analogues 6a, 6h and 6 u showed highe...

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Detalles Bibliográficos
Autores principales: Kumar, Prashant, Achieng, Angela O., Rajendran, Vinoth, Ghosh, Prahlad C., Singh, Brajendra K., Rawat, Manmeet, Perkins, Douglas J., Kempaiah, Prakasha, Rathi, Brijesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532363/
https://www.ncbi.nlm.nih.gov/pubmed/28751747
http://dx.doi.org/10.1038/s41598-017-06097-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532363/
https://www.ncbi.nlm.nih.gov/pubmed/28751747
http://dx.doi.org/10.1038/s41598-017-06097-z

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