Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products

Currently, DNA topoisomerase I (Topo I) inhibitors constitute a family of antitumor agents with demonstrated clinical effects on human malignancies. However, the clinical uses of these agents have been greatly limited due to their severe toxic effects. Therefore, it is urgent to find and develop nov...

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Detalles Bibliográficos
Autores principales: Xin, Lan-Ting, Liu, Lu, Shao, Chang-Lun, Yu, Ri-Lei, Chen, Fang-Ling, Yue, Shi-Jun, Wang, Mei, Guo, Zhong-Long, Fan, Ya-Chu, Guan, Hua-Shi, Wang, Chang-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532659/
https://www.ncbi.nlm.nih.gov/pubmed/28698495
http://dx.doi.org/10.3390/md15070217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532659/
https://www.ncbi.nlm.nih.gov/pubmed/28698495
http://dx.doi.org/10.3390/md15070217

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