Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to S(N)1 and S(N)2 Processes

[Image: see text] Classical methods for achieving nucleophilic substitutions of alkyl electrophiles (S(N)1 and S(N)2) have limited scope and are not generally amenable to enantioselective variants that employ readily available racemic electrophiles. Radical-based pathways catalyzed by chiral transit...

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Autor principal: Fu, Gregory C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532721/
https://www.ncbi.nlm.nih.gov/pubmed/28776010
http://dx.doi.org/10.1021/acscentsci.7b00212
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author Fu, Gregory C.
author_facet Fu, Gregory C.
author_sort Fu, Gregory C.
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description [Image: see text] Classical methods for achieving nucleophilic substitutions of alkyl electrophiles (S(N)1 and S(N)2) have limited scope and are not generally amenable to enantioselective variants that employ readily available racemic electrophiles. Radical-based pathways catalyzed by chiral transition-metal complexes provide an attractive approach to addressing these limitations.
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spelling pubmed-55327212017-08-03 Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to S(N)1 and S(N)2 Processes Fu, Gregory C. ACS Cent Sci [Image: see text] Classical methods for achieving nucleophilic substitutions of alkyl electrophiles (S(N)1 and S(N)2) have limited scope and are not generally amenable to enantioselective variants that employ readily available racemic electrophiles. Radical-based pathways catalyzed by chiral transition-metal complexes provide an attractive approach to addressing these limitations. American Chemical Society 2017-06-12 2017-07-26 /pmc/articles/PMC5532721/ /pubmed/28776010 http://dx.doi.org/10.1021/acscentsci.7b00212 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Fu, Gregory C.
Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to S(N)1 and S(N)2 Processes
title Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to S(N)1 and S(N)2 Processes
title_full Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to S(N)1 and S(N)2 Processes
title_fullStr Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to S(N)1 and S(N)2 Processes
title_full_unstemmed Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to S(N)1 and S(N)2 Processes
title_short Transition-Metal Catalysis of Nucleophilic Substitution Reactions: A Radical Alternative to S(N)1 and S(N)2 Processes
title_sort transition-metal catalysis of nucleophilic substitution reactions: a radical alternative to s(n)1 and s(n)2 processes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532721/
https://www.ncbi.nlm.nih.gov/pubmed/28776010
http://dx.doi.org/10.1021/acscentsci.7b00212
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