β‐Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α‐PP2A‐Mediated Dephosphorylation

BACKGROUND: Class IIa histone deacetylase (HDAC) isoforms such as HDAC5 are critical signal‐responsive repressors of maladaptive cardiomyocyte hypertrophy, through nuclear interactions with transcription factors including myocyte enhancer factor‐2. β‐Adrenoceptor (β‐AR) stimulation, a signal of fund...

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Detalles Bibliográficos
Autores principales: Weeks, Kate L., Ranieri, Antonella, Karaś, Agnieszka, Bernardo, Bianca C., Ashcroft, Alexandra S., Molenaar, Chris, McMullen, Julie R., Avkiran, Metin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533001/
https://www.ncbi.nlm.nih.gov/pubmed/28343149
http://dx.doi.org/10.1161/JAHA.116.004861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533001/
https://www.ncbi.nlm.nih.gov/pubmed/28343149
http://dx.doi.org/10.1161/JAHA.116.004861

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