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β‐Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α‐PP2A‐Mediated Dephosphorylation
BACKGROUND: Class IIa histone deacetylase (HDAC) isoforms such as HDAC5 are critical signal‐responsive repressors of maladaptive cardiomyocyte hypertrophy, through nuclear interactions with transcription factors including myocyte enhancer factor‐2. β‐Adrenoceptor (β‐AR) stimulation, a signal of fund...
Autores principales: | Weeks, Kate L., Ranieri, Antonella, Karaś, Agnieszka, Bernardo, Bianca C., Ashcroft, Alexandra S., Molenaar, Chris, McMullen, Julie R., Avkiran, Metin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533001/ https://www.ncbi.nlm.nih.gov/pubmed/28343149 http://dx.doi.org/10.1161/JAHA.116.004861 |
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