Hepatitis C Virus Subverts Human Choline Kinase-α To Bridge Phosphatidylinositol-4-Kinase IIIα (PI4KIIIα) and NS5A and Upregulates PI4KIIIα Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication

In this study, we elucidated the mechanism by which human choline kinase-α (hCKα) interacts with nonstructural protein 5A (NS5A) and phosphatidylinositol-4-kinase IIIα (PI4KIIIα), the lipid kinase crucial for maintaining the integrity of virus-induced membranous webs, and modulates hepatitis C virus...

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Detalles Bibliográficos
Autores principales: Wong, Mun-Teng, Chen, Steve S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533930/
https://www.ncbi.nlm.nih.gov/pubmed/28566381
http://dx.doi.org/10.1128/JVI.00355-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533930/
https://www.ncbi.nlm.nih.gov/pubmed/28566381
http://dx.doi.org/10.1128/JVI.00355-17

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