Sensitization of ASIC3 by proteinase-activated receptor 2 signaling contributes to acidosis-induced nociception

BACKGROUND: Tissue acidosis and inflammatory mediators play critical roles in pain. Pro-inflammatory agents trypsin and tryptase cleave and activate proteinase-activated receptor 2 (PAR(2)) expressed on sensory nerves, which is involved in peripheral mechanisms of inflammation and pain. Extracellula...

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Detalles Bibliográficos
Autores principales: Wu, Jing, Liu, Ting-Ting, Zhou, Yi-Mei, Qiu, Chun-Yu, Ren, Ping, Jiao, Ming, Hu, Wang-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534107/
https://www.ncbi.nlm.nih.gov/pubmed/28754162
http://dx.doi.org/10.1186/s12974-017-0916-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534107/
https://www.ncbi.nlm.nih.gov/pubmed/28754162
http://dx.doi.org/10.1186/s12974-017-0916-4

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