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Sensitization of ASIC3 by proteinase-activated receptor 2 signaling contributes to acidosis-induced nociception
BACKGROUND: Tissue acidosis and inflammatory mediators play critical roles in pain. Pro-inflammatory agents trypsin and tryptase cleave and activate proteinase-activated receptor 2 (PAR(2)) expressed on sensory nerves, which is involved in peripheral mechanisms of inflammation and pain. Extracellula...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534107/ https://www.ncbi.nlm.nih.gov/pubmed/28754162 http://dx.doi.org/10.1186/s12974-017-0916-4 |