Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase

OBJECTIVE: In order to explain the increased susceptibility to serious infection in alcoholic hepatitis, we evaluated monocyte phagocytosis, aberrations of associated signalling pathways and their reversibility, and whether phagocytic defects could predict subsequent infection. DESIGN: Monocytes wer...

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Detalles Bibliográficos
Autores principales: Vergis, Nikhil, Khamri, Wafa, Beale, Kylie, Sadiq, Fouzia, Aletrari, Mina O, Moore, Celia, Atkinson, Stephen R, Bernsmeier, Christine, Possamai, Lucia A, Petts, Gemma, Ryan, Jennifer M, Abeles, Robin D, James, Sarah, Foxton, Matthew, Hogan, Brian, Foster, Graham R, O'Brien, Alastair J, Ma, Yun, Shawcross, Debbie L, Wendon, Julia A, Antoniades, Charalambos G, Thursz, Mark R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534772/
https://www.ncbi.nlm.nih.gov/pubmed/26860769
http://dx.doi.org/10.1136/gutjnl-2015-310378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534772/
https://www.ncbi.nlm.nih.gov/pubmed/26860769
http://dx.doi.org/10.1136/gutjnl-2015-310378

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