Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin

Quinolin-6-yloxyacetamides (QAs) are a chemical class of tubulin polymerization inhibitors that were initially identified as fungicides. Here, we report that QAs are potent anti-proliferative agents against human cancer cells including ones that are drug-resistant. QAs act by disrupting the microtub...

Descripción completa

Detalles Bibliográficos
Autores principales: Sharma, Ashwani, Sáez-Calvo, Gonzalo, Olieric, Natacha, de Asís Balaguer, Francisco, Barasoain, Isabel, Lamberth, Clemens, Díaz, J. Fernando, Steinmetz, Michel O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535829/
https://www.ncbi.nlm.nih.gov/pubmed/28640209
http://dx.doi.org/10.3390/ijms18071336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535829/
https://www.ncbi.nlm.nih.gov/pubmed/28640209
http://dx.doi.org/10.3390/ijms18071336

Ejemplares similares