LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes

Metabolic endotoxemia contributes to low-grade inflammation in obesity, which causes insulin resistance due to the activation of intracellular proinflammatory pathways, such as the c-Jun N-terminal Kinase (JNK) cascade in the hypothalamus and other tissues. However, it remains unclear whether the pr...

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Detalles Bibliográficos
Autores principales: Rorato, Rodrigo, Borges, Beatriz de Carvalho, Uchoa, Ernane Torres, Antunes-Rodrigues, José, Elias, Carol Fuzeti, Elias, Lucila Leico Kagohara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535922/
https://www.ncbi.nlm.nih.gov/pubmed/28677618
http://dx.doi.org/10.3390/ijms18071431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535922/
https://www.ncbi.nlm.nih.gov/pubmed/28677618
http://dx.doi.org/10.3390/ijms18071431

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