Cargando…

LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes

Metabolic endotoxemia contributes to low-grade inflammation in obesity, which causes insulin resistance due to the activation of intracellular proinflammatory pathways, such as the c-Jun N-terminal Kinase (JNK) cascade in the hypothalamus and other tissues. However, it remains unclear whether the pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rorato, Rodrigo, Borges, Beatriz de Carvalho, Uchoa, Ernane Torres, Antunes-Rodrigues, José, Elias, Carol Fuzeti, Elias, Lucila Leico Kagohara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535922/ https://www.ncbi.nlm.nih.gov/pubmed/28677618 http://dx.doi.org/10.3390/ijms18071431

Ejemplares similares

SUN-248 Estradiol Changes Angiotensin II-Induced ERK1/2 Phosphorylation by Different Pathways in the Hypothalamus and Lamina Terminalis
por: Almeida-Pereira, Gislaine, et al.
Publicado: (2020)

Restricted Feeding Schedules Modulate in a Different Manner the Expression of Clock Genes in Rat Hypothalamic Nuclei
por: De Araujo, Leonardo D., et al.
Publicado: (2016)

PI3K p110β subunit in leptin receptor expressing cells is required for the acute hypophagia induced by endotoxemia
por: Borges, Beatriz C., et al.
Publicado: (2016)

Prolonged Activation of Brain CB2 Signaling Modulates Hypothalamic Microgliosis and Astrogliosis in High Fat Diet-Fed Mice
por: Rorato, Rodrigo, et al.
Publicado: (2022)

Correction to: Arcuate AgRP, but not POMC neurons, modulate paraventricular CRF synthesis and release in response to fasting
por: Fernandes, Alan Carlos Alves, et al.
Publicado: (2022)

Arcuate AgRP, but not POMC neurons, modulate paraventricular CRF synthesis and release in response to fasting
por: Fernandes, Alan Carlos Alves, et al.
Publicado: (2022)

Effects of Estrogen Therapy on the Serotonergic System in an Animal Model of Perimenopause Induced by 4-Vinylcyclohexen Diepoxide (VCD)
por: Pestana-Oliveira, Nayara, et al.
Publicado: (2018)

The Ventral Premammillary Nucleus Links Metabolic Cues and Reproduction
por: Donato, Jose, et al.
Publicado: (2011)

Sex differences in the coexpression of prokineticin receptor 2 and gonadal steroids receptors in mice
por: Cisneros-Larios, Brenda, et al.
Publicado: (2023)

Glial cell activity is maintained during prolonged inflammatory challenge in rats
por: Borges, B.C., et al.
Publicado: (2012)

Restricted feeding modulates peripheral clocks and nutrient sensing pathways in rats
por: Rodrigues, Luis Guilherme F., et al.
Publicado: (2021)

MON-637 DREADD-Induced POMC(ARC)Neuron Activation Increases Fasting Plasma Glucose Levels Through Changes in Hepatic Gluconeogenic Gene Expression but Not Changes in the HPA Axis Activity
por: Vieira, Luane da Guia, et al.
Publicado: (2020)

Analysis of Hypothalamic TRH Neurons in Regulating Thyroid Hormone Levels
por: Costa e Sousa, Ricardo H, et al.
Publicado: (2021)

Benefits of SGLT2i for the Treatment of Heart Failure Irrespective of Diabetes Diagnosis: A State-of-the-Art Review
por: Delgado, Elías, et al.
Publicado: (2022)

Intraosseous conventional central chondrosarcoma does not metastasise irrespective of grade in pelvis, scapula and in long bone locations
por: Laitinen, Minna K., et al.
Publicado: (2023)

SUN-117 Neuroendocrine Mechanisms Responsible for the Hydromineral Control in Rats with Obesity Induced by High Fat Diet (HFD)
por: De Araujo, Leonardo, et al.
Publicado: (2019)

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance
por: Martínez-Sánchez, Noelia, et al.
Publicado: (2017)

Panhypopituitarism in a patient with a hypothalamic and pineal germ cell tumor
por: Puchalski, Adam, et al.
Publicado: (2022)

Investigating the role of P38, JNK and ERK in LPS induced hippocampal insulin resistance and spatial memory impairment: effects of insulin treatment
por: Iloun, Parisa, et al.
Publicado: (2018)

JNK Signaling Pathway Suppresses LPS-Mediated Apoptosis of HK-2 Cells by Upregulating NGAL
por: Han, Mei, et al.
Publicado: (2020)

Necroptosis Contributes to LPS-Induced Activation of the Hypothalamic-Pituitary-Adrenal Axis in a Piglet Model
por: Zhou, Bei, et al.
Publicado: (2022)

Using Intermittent Fasting as a Non-pharmacological Strategy to Alleviate Obesity-Induced Hypothalamic Molecular Pathway Disruption
por: Oliveira, Luciana da Costa, et al.
Publicado: (2022)

Workplace Anger Costs Women Irrespective of Race
por: Marshburn, Christopher K., et al.
Publicado: (2020)

Central nitrergic system regulation of neuroendocrine secretion, fluid intake and blood pressure induced by angiotensin-II
por: Reis, Wagner L, et al.
Publicado: (2010)

Circadian Alterations in a Murine Model of Hypothalamic Glioma
por: Duhart, José M., et al.
Publicado: (2017)

Evaluation of the hypothalamic–pituitary–adrenal axis in a case series of familial partial lipodystrophy
por: Elias, Cecília Pacheco, et al.
Publicado: (2019)

Acetylation of HMGB1 by JNK1 Signaling Promotes LPS-Induced Peritoneal Mesothelial Cells Apoptosis
por: Cao, Shirong, et al.
Publicado: (2018)

Sulfated Chitosan Oligosaccharides Suppress LPS-Induced NO Production via JNK and NF-κB Inactivation
por: Kim, Jung-Hyun, et al.
Publicado: (2014)

JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis
por: Khan, Meraj A., et al.
Publicado: (2017)

Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury
por: Xiao, Zhongxiang, et al.
Publicado: (2019)

An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis
por: Li, Rongrong, et al.
Publicado: (2021)

Undetectable measurable residual disease is associated with improved outcomes in AML irrespective of treatment intensity
por: Bazinet, Alexandre, et al.
Publicado: (2023)

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
por: Cameron, Amy R., et al.
Publicado: (2016)

Thoracic Surgery for Malignancy and Emergency Irrespective of COVID-19
por: Maurizi, Giulio, et al.
Publicado: (2020)

Inhibition of JNK Phosphorylation by Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury [Corrigendum]
Publicado: (2022)

Microglial activation induced by LPS mediates excitation of neurons in the hypothalamic paraventricular nucleus projecting to the rostral ventrolateral medulla
por: Han, Tae Hee, et al.
Publicado: (2021)

Economic and epidemiologic impact of guidelines for early ART initiation irrespective of CD4 count in Spain
por: Kasaie, Parastu, et al.
Publicado: (2018)

Saccades predict and synchronize to visual rhythms irrespective of musical beats
por: Batten, Jonathan P., et al.
Publicado: (2018)

Coronary calcification compromises myocardial perfusion irrespective of luminal stenosis
por: Henein, Michael Y., et al.
Publicado: (2016)

iNOS promotes hypothalamic insulin resistance associated with deregulation of energy balance and obesity in rodents
por: Katashima, Carlos Kiyoshi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_5g6gh5od2ce3npuiabbh4bantt