Cargando…

Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells

Disturbances in histone acetyltransferases (HATs) are common in cancers. In urothelial carcinoma (UC), p300 and CBP are often mutated, whereas the GNAT family HATs GCN5 and PCAF (General Control Nonderepressible 5, p300/CBP-Associated Factor) are often upregulated. Here, we explored the effects of s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koutsogiannouli, Evangelia A., Wagner, Nicholas, Hader, Christiane, Pinkerneil, Maria, Hoffmann, Michèle J., Schulz, Wolfgang A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535940/ https://www.ncbi.nlm.nih.gov/pubmed/28678170 http://dx.doi.org/10.3390/ijms18071449

Ejemplares similares

Posttranslational regulation of the GCN5 and PCAF acetyltransferases
por: Ononye, Onyekachi E., et al.
Publicado: (2022)

Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5
por: Hatakeyama, Dai, et al.
Publicado: (2018)

Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice
por: Oksenych, Valentyn, et al.
Publicado: (2021)

Opposite effects of GCN5 and PCAF knockdowns on the alternative mechanism of telomere maintenance
por: Jeitany, Maya, et al.
Publicado: (2017)

The New Immortalized Uroepithelial Cell Line HBLAK Contains Defined Genetic Aberrations Typical of Early Stage Urothelial Tumors
por: Hoffmann, Michèle J., et al.
Publicado: (2016)

Gcn5 histone acetyltransferase is present in the mitoplasts
por: Montanari, Arianna, et al.
Publicado: (2019)

And-1 is required for the stability of histone acetyltransferase Gcn5
por: Li, Yongming, et al.
Publicado: (2011)

Investigation of the Acetylation Mechanism by GCN5 Histone Acetyltransferase
por: Jiang, Junfeng, et al.
Publicado: (2012)

Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells
por: Liu, Yujie, et al.
Publicado: (2019)

GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action
por: Lew, Qiao Jing, et al.
Publicado: (2014)

Diversification of the Histone Acetyltransferase GCN5 through Alternative Splicing in Brachypodium distachyon
por: Martel, Alexandre, et al.
Publicado: (2017)

Histone acetyltransferase PCAF Up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling
por: Zheng, Xin, et al.
Publicado: (2013)

Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma
por: Gai, X, et al.
Publicado: (2015)

Inhibition of PCAF Histone Acetyltransferase, Cytotoxicity and Cell Permeability of 2-Acylamino-1-(3- or 4-Carboxy-phenyl)benzamides
por: Park, Woong Jae, et al.
Publicado: (2012)

Correction: Histone acetyltransferase PCAF Up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling
por: Zheng, Xin, et al.
Publicado: (2022)

The Sas3p and Gcn5p histone acetyltransferases are recruited to similar genes
por: Rosaleny, Lorena E, et al.
Publicado: (2007)

Histone Acetyltransferase CfGcn5-Mediated Autophagy Governs the Pathogenicity of Colletotrichum fructicola
por: Zhang, Shengpei, et al.
Publicado: (2022)

Combined inhibition of BET proteins and class I HDACs synergistically induces apoptosis in urothelial carcinoma cell lines
por: Hölscher, Alexander S., et al.
Publicado: (2018)

The Chromatin Remodeling Factor CSB Recruits Histone Acetyltransferase PCAF to rRNA Gene Promoters in Active State for Transcription Initiation
por: Shen, Meili, et al.
Publicado: (2013)

Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines
por: Pinkerneil, Maria, et al.
Publicado: (2016)

The Aspergillus flavus Histone Acetyltransferase AflGcnE Regulates Morphogenesis, Aflatoxin Biosynthesis, and Pathogenicity
por: Lan, Huahui, et al.
Publicado: (2016)

Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines
por: Huang, Boyue, et al.
Publicado: (2020)

Histone Acetyltransferase SlGCN5 Regulates Shoot Meristem and Flower Development in Solanum lycopersicum
por: Hawar, Amangul, et al.
Publicado: (2022)

Functional Characterization of the GNAT Family Histone Acetyltransferase Elp3 and GcnE in Aspergillus fumigatus
por: Choi, Young-Ho, et al.
Publicado: (2023)

Acetyltransferase p300/CBP Associated Factor (PCAF) Regulates Crosstalk-Dependent Acetylation of Histone H3 by Distal Site Recognition
por: Kornacki, James R., et al.
Publicado: (2014)

Epigenetically Down-Regulated Acetyltransferase PCAF Increases the Resistance of Colorectal Cancer to 5-Fluorouracil()
por: Liu, Tong, et al.
Publicado: (2019)

Distinct roles of the Gcn5 histone acetyltransferase revealed during transient stress-induced reprogramming of the genome
por: Xue-Franzén, Yongtao, et al.
Publicado: (2013)

Histone Acetyltransferase GCN5 Affects Auxin Transport during Root Growth by Modulating Histone Acetylation and Gene Expression of PINs
por: Poulios, Stylianos, et al.
Publicado: (2022)

Contingencies of UTX/KDM6A Action in Urothelial Carcinoma
por: Lang, Alexander, et al.
Publicado: (2019)

Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine
por: Isono, Makoto, et al.
Publicado: (2017)

The histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect trichome initiation in Arabidopsis thaliana
por: Hark, Amy T, et al.
Publicado: (2019)

Histone acetyltransferase PfGCN5 regulates stress responsive and artemisinin resistance related genes in Plasmodium falciparum
por: Rawat, Mukul, et al.
Publicado: (2021)

The Histone Acetyltransferase HpGCN5 Involved in the Regulation of Abiotic Stress Responses and Astaxanthin Accumulation in Haematococcus pluvialis
por: Huang, Danqiong, et al.
Publicado: (2022)

In-vitro acetylation of SARS-CoV and SARS-CoV-2 nucleocapsid proteins by human PCAF and GCN5
por: Hatakeyama, Dai, et al.
Publicado: (2021)

The Spt-Ada-Gcn5 Acetyltransferase (SAGA) Complex in Aspergillus nidulans
por: Georgakopoulos, Paraskevi, et al.
Publicado: (2013)

Characterization of yeast histone H3-specific type B histone acetyltransferases identifies an ADA2-independent Gcn5p activity
por: Sklenar, Amy R, et al.
Publicado: (2004)

Does gene length play a role? — Transient regulation of Gcn5 histone acetyltransferase under stress conditions
por: Xue-Franzén, Yongtao
Publicado: (2014)

Disruption of the histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect trichome density in Arabidopsis thaliana
por: Kotak, Jenna, et al.
Publicado: (2019)

The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in Plants
por: Vlachonasios, Konstantinos, et al.
Publicado: (2021)

A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum
por: Miao, Jun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_u9cj9im4djk0e0ieidciklbarh