Inhibitory Effects of Trapping Agents of Sulfur Drug Reactive Intermediates against Major Human Cytochrome P450 Isoforms

In some cases, the formation of reactive species from the metabolism of xenobiotics has been linked to toxicity and therefore it is imperative to detect potential bioactivation for candidate drugs during drug discovery. Reactive species can covalently bind to trapping agents in in vitro incubations...

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Detalles Bibliográficos
Autores principales: Sodhi, Jasleen K., Delarosa, Erlie Marie, Halladay, Jason S., Driscoll, James P., Mulder, Teresa, Dansette, Patrick M., Khojasteh, S. Cyrus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536041/
https://www.ncbi.nlm.nih.gov/pubmed/28726718
http://dx.doi.org/10.3390/ijms18071553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536041/
https://www.ncbi.nlm.nih.gov/pubmed/28726718
http://dx.doi.org/10.3390/ijms18071553

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