Proteostasis of Huntingtin in Health and Disease

Huntington’s disease (HD) is a fatal neurodegenerative disorder characterized by motor dysfunction, cognitive deficits and psychosis. HD is caused by mutations in the Huntingtin (HTT) gene, resulting in the expansion of polyglutamine (polyQ) repeats in the HTT protein. Mutant HTT is prone to aggrega...

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Detalles Bibliográficos
Autores principales: Koyuncu, Seda, Fatima, Azra, Gutierrez-Garcia, Ricardo, Vilchez, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536056/
https://www.ncbi.nlm.nih.gov/pubmed/28753941
http://dx.doi.org/10.3390/ijms18071568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536056/
https://www.ncbi.nlm.nih.gov/pubmed/28753941
http://dx.doi.org/10.3390/ijms18071568

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