Cargando…

Proteostasis of Huntingtin in Health and Disease

Huntington’s disease (HD) is a fatal neurodegenerative disorder characterized by motor dysfunction, cognitive deficits and psychosis. HD is caused by mutations in the Huntingtin (HTT) gene, resulting in the expansion of polyglutamine (polyQ) repeats in the HTT protein. Mutant HTT is prone to aggrega...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koyuncu, Seda, Fatima, Azra, Gutierrez-Garcia, Ricardo, Vilchez, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536056/ https://www.ncbi.nlm.nih.gov/pubmed/28753941 http://dx.doi.org/10.3390/ijms18071568

Ejemplares similares

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
por: Koyuncu, Seda, et al.
Publicado: (2018)

Author Correction: The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
por: Koyuncu, Seda, et al.
Publicado: (2020)

Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
por: Noormohammadi, Alireza, et al.
Publicado: (2016)

Insights Into the Links Between Proteostasis and Aging From C. elegans
por: Zhang, William Hongyu, et al.
Publicado: (2022)

G3BP1-dependent mechanism suppressing protein aggregation in Huntington’s models and its demise upon stress granule assembly
por: Gutiérrez-Garcia, Ricardo, et al.
Publicado: (2023)

Induced pluripotent stem cells from Huntington’s disease patients: a promising approach to define and correct disease-related alterations
por: Fatima, Azra, et al.
Publicado: (2019)

Insights into the ubiquitin-proteasome system of human embryonic stem cells
por: Saez, Isabel, et al.
Publicado: (2018)

In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation
por: Llamas, Ernesto, et al.
Publicado: (2023)

Huntingtin and Its Partner Huntingtin-Associated Protein 40: Structural and Functional Considerations in Health and Disease
por: Seefelder, Manuel, et al.
Publicado: (2022)

Mediation of organismal aging and somatic proteostasis by the germline
por: Khodakarami, Amirabbas, et al.
Publicado: (2015)

Emerging Therapies for Huntington’s Disease – Focus on N-Terminal Huntingtin and Huntingtin Exon 1
por: van der Bent, M Leontien, et al.
Publicado: (2022)

Post-transcriptional negative feedback regulation of proteostasis through the Dis3 ribonuclease and its disruption by polyQ-expanded Huntingtin
por: Kong, Ka-Yiu Edwin, et al.
Publicado: (2019)

Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease
por: Sherman, David J., et al.
Publicado: (2020)

Protein Folding and Mechanisms of Proteostasis
por: Díaz-Villanueva, José Fernando, et al.
Publicado: (2015)

Pathways of cellular proteostasis in aging and disease
por: Klaips, Courtney L., et al.
Publicado: (2018)

Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases
por: Sonninen, Tuuli-Maria, et al.
Publicado: (2020)

Chaperones and Proteostasis: Role in Parkinson’s Disease
por: Joshi, Neha, et al.
Publicado: (2020)

LRRK2 and Proteostasis in Parkinson’s Disease
por: Pérez-Carrión, María Dolores, et al.
Publicado: (2022)

Huntingtin Lowering Strategies
por: Marxreiter, Franz, et al.
Publicado: (2020)

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes
por: Lee, Hyun Ju, et al.
Publicado: (2023)

Huntingtin Ubiquitination Mechanisms and Novel Possible Therapies to Decrease the Toxic Effects of Mutated Huntingtin
por: Fiorillo, Annarita, et al.
Publicado: (2021)

The Role of Hsp90 in Retinal Proteostasis and Disease
por: Ziaka, Kalliopi, et al.
Publicado: (2022)

Is Huntingtin Dispensable in the Adult Brain?
por: Liu, Jeh-Ping, et al.
Publicado: (2017)

Transcriptional Regulation of the Huntingtin Gene
por: Thomson, Sarah B., et al.
Publicado: (2018)

Proteostasis in pediatric pulmonary pathology
por: Meiners, Silke, et al.
Publicado: (2014)

The Contribution of the 20S Proteasome to Proteostasis
por: Kumar Deshmukh, Fanindra, et al.
Publicado: (2019)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases
por: Li, Jin, et al.
Publicado: (2018)

Therapeutic Approaches Targeting Proteostasis in Kidney Disease and Fibrosis
por: Chen, Jia-Huang, et al.
Publicado: (2021)

TRIM family proteins: roles in proteostasis and neurodegenerative diseases
por: Zhu, Yan, et al.
Publicado: (2022)

The Role of Exercise in Maintaining Mitochondrial Proteostasis in Parkinson’s Disease
por: Li, Jingwen, et al.
Publicado: (2023)

Huntingtin Interacting Proteins and Pathological Implications
por: Liu, Li, et al.
Publicado: (2023)

Reversible protein assemblies in the proteostasis network in health and disease
por: Kohler, Verena, et al.
Publicado: (2023)

Huntingtin and the Synapse
por: Barron, Jessica C., et al.
Publicado: (2021)

Proteostasis and Diseases of the Motor Unit
por: Rinaldi, Carlo, et al.
Publicado: (2016)

Rewiring of the ubiquitinated proteome determines ageing in C. elegans
por: Koyuncu, Seda, et al.
Publicado: (2021)

Proteostasis, oxidative stress and aging
por: Korovila, Ioanna, et al.
Publicado: (2017)

Neuroprotective effects of hepatoma-derived growth factor in models of Huntington’s disease
por: Voelkl, Kerstin, et al.
Publicado: (2023)

Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
por: Höhn, Annika, et al.
Publicado: (2020)

Endoplasmic reticulum proteostasis impairment in aging
por: Martínez, Gabriela, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bkog0sqp0f4ttuon6l8rbvt12q