Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies

Genome-wide association studies (GWAS) have identified hundreds of SNPs responsible for variation in human quantitative traits. However, genome-wide-significant associations often fail to replicate across independent cohorts, in apparent inconsistency with their apparent strong effects in discovery...

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Detalles Bibliográficos
Autores principales: Palmer, Cameron, Pe’er, Itsik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536394/
https://www.ncbi.nlm.nih.gov/pubmed/28715421
http://dx.doi.org/10.1371/journal.pgen.1006916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536394/
https://www.ncbi.nlm.nih.gov/pubmed/28715421
http://dx.doi.org/10.1371/journal.pgen.1006916

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