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Blood vessel tortuosity selects against evolution of aggressive tumor cells in confined tissue environments: A modeling approach
Cancer is a disease of cellular regulation, often initiated by genetic mutation within cells, and leading to a heterogeneous cell population within tissues. In the competition for nutrients and growth space within the tumors the phenotype of each cell determines its success. Selection in this proces...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536454/ https://www.ncbi.nlm.nih.gov/pubmed/28715420 http://dx.doi.org/10.1371/journal.pcbi.1005635 |