Bone marrow adipocytes promote the regeneration of stem cells and hematopoiesis by secreting SCF

Endothelial cells and Leptin Receptor(+) (LepR(+)) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including Stem Cell Factor (SCF), in bone marrow. After irradiation or chemotherapy, these cells are depleted while adipocytes become abundant. We discovered that bo...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Bo O., Yu, Hua, Yue, Rui, Zhao, Zhiyu, Rios, Jonathan J., Naveiras, Olaia, Morrison, Sean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536858/
https://www.ncbi.nlm.nih.gov/pubmed/28714970
http://dx.doi.org/10.1038/ncb3570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536858/
https://www.ncbi.nlm.nih.gov/pubmed/28714970
http://dx.doi.org/10.1038/ncb3570

Ejemplares similares