VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels

Visual information is relayed from the eye to the brain via retinal ganglion cell (RGC) axons. Mice lacking NRP1 or NRP1-binding VEGF-A isoforms have defective RGC axon organisation alongside brain vascular defects. It is not known whether axonal defects are caused exclusively by defective VEGF-A si...

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Detalles Bibliográficos
Autores principales: Erskine, Lynda, François, Urielle, Denti, Laura, Joyce, Andy, Tillo, Miguel, Bruce, Freyja, Vargesson, Neil, Ruhrberg, Christiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536872/
https://www.ncbi.nlm.nih.gov/pubmed/28676569
http://dx.doi.org/10.1242/dev.151621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536872/
https://www.ncbi.nlm.nih.gov/pubmed/28676569
http://dx.doi.org/10.1242/dev.151621

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