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Dynamic changes in the mouse skeletal muscle proteome during denervation-induced atrophy

Loss of neuronal stimulation enhances protein breakdown and reduces protein synthesis, causing rapid loss of muscle mass. To elucidate the pathophysiological adaptations that occur in atrophying muscles, we used stable isotope labelling and mass spectrometry to quantify protein expression changes ac...

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Detalles Bibliográficos
Autores principales: Lang, Franziska, Aravamudhan, Sriram, Nolte, Hendrik, Türk, Clara, Hölper, Soraya, Müller, Stefan, Günther, Stefan, Blaauw, Bert, Braun, Thomas, Krüger, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536905/
https://www.ncbi.nlm.nih.gov/pubmed/28546288
http://dx.doi.org/10.1242/dmm.028910