A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome

Genetic changes are infrequent in acute myeloid leukemia (AML) compared to other malignancies and often involve epigenetic regulators, suggesting that an altered epigenome may underlie AML biology and outcomes. In 96 AML cases including 65 pilot samples selected for cured/not-cured, we found higher...

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Detalles Bibliográficos
Autores principales: Kelly, Andrew D., Kroeger, Heike, Yamazaki, Jumpei, Taby, Rodolphe, Neumann, Frank, Yu, Sijia, Lee, Justin T., Patel, Bela, Li, Yuesheng, He, Rong, Liang, Shoudan, Lu, Yue, Cesaroni, Matteo, Pierce, Sherry A., Kornblau, Steven M., Bueso-Ramos, Carlos E., Ravandi, Farhad, Kantarjian, Hagop M., Jelinek, Jaroslav, Issa, Jean-Pierre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537054/
https://www.ncbi.nlm.nih.gov/pubmed/28074068
http://dx.doi.org/10.1038/leu.2017.12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537054/
https://www.ncbi.nlm.nih.gov/pubmed/28074068
http://dx.doi.org/10.1038/leu.2017.12

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