Exendin-4 reduces food intake via the PI3K/AKT signaling pathway in the hypothalamus

Exendin-4 (EX-4), a glucagon-like peptide-1 (GLP-1) receptor agonist, has been shown to reduce food intake and to increase proopiomelanocortin (POMC) gene expression in the hypothalamus. In this study, we examined the potential neural mechanisms by which these effects occur. Male Sprague Dawley rats...

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Detalles Bibliográficos
Autores principales: Yang, Yan, Choi, Pique P., Smith, Wanli W., Xu, Weijie, Ma, Delin, Cordner, Zachary A., Liang, Nu-Chu, Moran, Timothy H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537284/
https://www.ncbi.nlm.nih.gov/pubmed/28761132
http://dx.doi.org/10.1038/s41598-017-06951-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537284/
https://www.ncbi.nlm.nih.gov/pubmed/28761132
http://dx.doi.org/10.1038/s41598-017-06951-0

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