Spatial structure of TLR4 transmembrane domain in bicelles provides the insight into the receptor activation mechanism

Toll-like receptors (TLRs) play a key role in the innate and adaptive immune systems. While a lot of structural data is available for the extracellular and cytoplasmic domains of TLRs, and a model of the dimeric full-length TLR3 receptor in the active state was build, the conformation of the transme...

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Detalles Bibliográficos
Autores principales: Mineev, Konstantin S., Goncharuk, Sergey A., Goncharuk, Marina V., Volynsky, Pavel E., Novikova, Ekaterina V., Aresinev, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537299/
https://www.ncbi.nlm.nih.gov/pubmed/28761155
http://dx.doi.org/10.1038/s41598-017-07250-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537299/
https://www.ncbi.nlm.nih.gov/pubmed/28761155
http://dx.doi.org/10.1038/s41598-017-07250-4

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