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Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity
Deterioration of pancreatic beta-cells plays a critical role in the development of type 2 diabetes. Among the various stressors contributing to these deleterious effects, glucotoxicity and superoxides have been proposed as major players. In this context, the mitochondrial uncoupling protein UCP2 is...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537434/ https://www.ncbi.nlm.nih.gov/pubmed/28755631 http://dx.doi.org/10.1016/j.redox.2017.07.012 |