Truncating mutations in SPAST patients are associated with a high rate of psychiatric comorbidities in hereditary spastic paraplegia

BACKGROUND: The hereditary spastic paraplegias (HSPs) are a rare and heterogeneous group of neurodegenerative disorders that are clinically characterised by progressive lower limb spasticity. They are classified as either ‘pure’ or ‘complex’ where spastic paraplegia is complicated with additional ne...

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Detalles Bibliográficos
Autores principales: Chelban, Viorica, Tucci, Arianna, Lynch, David S, Polke, James M, Santos, Liana, Jonvik, Hallgeir, Groppa, Stanislav, Wood, Nicholas W, Houlden, Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of Neurology, Neurosurgery, and Psychiatry 2017
Materias:
Neurogenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537546/
https://www.ncbi.nlm.nih.gov/pubmed/28572275
http://dx.doi.org/10.1136/jnnp-2017-315796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537546/
https://www.ncbi.nlm.nih.gov/pubmed/28572275
http://dx.doi.org/10.1136/jnnp-2017-315796

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