eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet

BACKGROUND: Dietary fructose can rapidly cause fatty liver in animals through de novo lipogenesis (DNL) and contribute to the development and severity of nonalcoholic fatty liver disease (NAFLD). In response to diverse cellular insults including endoplasmic reticulum (ER) and oxidative stress, phosp...

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Detalles Bibliográficos
Autores principales: Choi, Woo-Gyun, Han, Jaeseok, Kim, Ji-Hyeon, Kim, Mi-Jeong, Park, Jae-Woo, Song, Benbo, Cha, Hee-Jeong, Choi, Hye-Seon, Chung, Hun-Taeg, Lee, In-Kyu, Park, Tae-Sik, Hatzoglou, Maria, Choi, Hueng-Sik, Yoo, Hyun Ju, Kaufman, Randal J., Back, Sung Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537942/
https://www.ncbi.nlm.nih.gov/pubmed/28781602
http://dx.doi.org/10.1186/s12986-017-0202-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537942/
https://www.ncbi.nlm.nih.gov/pubmed/28781602
http://dx.doi.org/10.1186/s12986-017-0202-6

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