Cargando…

eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet

BACKGROUND: Dietary fructose can rapidly cause fatty liver in animals through de novo lipogenesis (DNL) and contribute to the development and severity of nonalcoholic fatty liver disease (NAFLD). In response to diverse cellular insults including endoplasmic reticulum (ER) and oxidative stress, phosp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Woo-Gyun, Han, Jaeseok, Kim, Ji-Hyeon, Kim, Mi-Jeong, Park, Jae-Woo, Song, Benbo, Cha, Hee-Jeong, Choi, Hye-Seon, Chung, Hun-Taeg, Lee, In-Kyu, Park, Tae-Sik, Hatzoglou, Maria, Choi, Hueng-Sik, Yoo, Hyun Ju, Kaufman, Randal J., Back, Sung Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537942/ https://www.ncbi.nlm.nih.gov/pubmed/28781602 http://dx.doi.org/10.1186/s12986-017-0202-6

Ejemplares similares

Reduced EGFR Level in eIF2α Phosphorylation-Deficient Hepatocytes Is Responsible for Susceptibility to Oxidative Stress
por: Kim, Mi-Jeong, et al.
Publicado: (2020)

Epigallocatechin-3-Gallate Suppresses BMP-6-Mediated SMAD1/5/8 Transactivation of Hepcidin Gene by Inducing SMILE in Hepatocytes
por: Kim, Yu-Ji, et al.
Publicado: (2021)

Melatonin Regulates Iron Homeostasis by Inducing Hepcidin Expression in Hepatocytes
por: Park, Woo-Ram, et al.
Publicado: (2022)

Assessing the reproducibility of high temporal and spatial resolution dynamic contrast-enhanced magnetic resonance imaging in patients with gliomas
por: Lim, Woo Hyeon, et al.
Publicado: (2021)

Transcriptional cross talk between orphan nuclear receptor ERRγ and transmembrane transcription factor ATF6α coordinates endoplasmic reticulum stress response
por: Misra, Jagannath, et al.
Publicado: (2013)

Orphan Nuclear Receptor ERRγ Is a Transcriptional Regulator of CB1 Receptor-Mediated TFR2 Gene Expression in Hepatocytes
por: Kim, Bo-Eun, et al.
Publicado: (2021)

Acute liver injury induces expression of FGF23 in hepatocytes via orphan nuclear receptor ERRγ signaling
por: Jung, Yoon Seok, et al.
Publicado: (2022)

CD38 Inhibition Protects Fructose-Induced Toxicity in Primary Hepatocytes
por: Lee, Soo-Jin, et al.
Publicado: (2023)

Phosphorylation of eIF2α at Serine 51 Is an Important Determinant of Cell Survival and Adaptation to Glucose Deficiency
por: Muaddi, Hala, et al.
Publicado: (2010)

Effects of Prostaglandins on Ethanol Damage in Primary Cultured Rat Hepatocytes
por: Yang, Jin Mo, et al.
Publicado: (1998)

Hepatocyte DAX1 Deletion Exacerbates Inflammatory Liver Injury by Inducing the Recruitment of CD4(+) and CD8(+) T Cells through NF-κB p65 Signaling Pathway in Mice
por: Yun, Hyo-Jeong, et al.
Publicado: (2022)

Deficiency of fibroblast growth factor 21 aggravates obesity-induced atrophic responses in skeletal muscle
por: Kim, Chu-Sook, et al.
Publicado: (2019)

Renoprotective and antioxidant effects of Saururus chinensis Baill in rats fed a high-fructose diet
por: Choi, Ha-Neul, et al.
Publicado: (2011)

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis
por: Han, Jaeseok, et al.
Publicado: (2015)

PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila
por: Elvira, Rosalie, et al.
Publicado: (2020)

Epigallocatechin-3-Gallate (EGCG)-Inducible SMILE Inhibits STAT3-Mediated Hepcidin Gene Expression
por: Kim, Yu-Ji, et al.
Publicado: (2020)

Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression
por: Lee, Yong-Soo, et al.
Publicado: (2017)

Rv2299c, a novel dendritic cell-activating antigen of Mycobacterium tuberculosis, fused-ESAT-6 subunit vaccine confers improved and durable protection against the hypervirulent strain HN878 in mice
por: Choi, Han-Gyu, et al.
Publicado: (2017)

Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells
por: Lee, Jinju, et al.
Publicado: (2022)

Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress–induced cell death during the unfolded protein response
por: Hiramatsu, Nobuhiko, et al.
Publicado: (2014)

Metabolic Stability of D-Allulose in Biorelevant Media and Hepatocytes: Comparison with Fructose and Erythritol
por: Maeng, Han-Joo, et al.
Publicado: (2019)

Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation
por: Noh, Jung-Ran, et al.
Publicado: (2018)

Stabilization of Sur8 via PKCα/δ degradation promotes transformation and migration of colorectal cancer cells
por: Lee, Kug Hwa, et al.
Publicado: (2017)

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes
por: Park, Han-Jin, et al.
Publicado: (2015)

A Study on the Effects of Muscarinic and Serotonergic Regulation by Bojanggunbi-tang on the Pacemaker Potential of the Interstitial Cells of Cajal in the Murine Small Intestine
por: Choi, Na Ri, et al.
Publicado: (2023)

eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B
por: Kim, Eunah, et al.
Publicado: (2018)

Overexpression of S-Adenosylmethionine Synthetase in Recombinant Chlamydomonas for Enhanced Lipid Production
por: Kim, Jeong Hyeon, et al.
Publicado: (2023)

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab
por: Lee, Sang-Kyu, et al.
Publicado: (2018)

Functional 3D Human Primary Hepatocyte Spheroids Made by Co-Culturing Hepatocytes from Partial Hepatectomy Specimens and Human Adipose-Derived Stem Cells
por: No, Da Yoon, et al.
Publicado: (2012)

Retraction Note: Distinct Repressive Properties of the Mammalian and Fish Orphan Nuclear Receptors SHP and DAX-1
por: Park, Yun-Yong, et al.
Publicado: (2018)

Emerging Role of SMILE in Liver Metabolism
por: Sadasivam, Nanthini, et al.
Publicado: (2023)

Free Flap Reconstruction of Head and Neck Defects after Oncologic Ablation: One Surgeon's Outcomes in 42 Cases
por: Lim, Yun Sub, et al.
Publicado: (2014)

Physiological/pathological ramifications of transcription factors in the unfolded protein response
por: Han, Jaeseok, et al.
Publicado: (2017)

Comparison of clinical result between early laparoscopic cholecystectomy and delayed laparoscopic cholecystectomy after percutaneous transhepatic gallbladder drainage for patients with complicated acute cholecystitis
por: Choi, Jae Woo, et al.
Publicado: (2012)

Hereditary Fructose Intolerance Diagnosed in Adulthood
por: Kim, Min Soo, et al.
Publicado: (2021)

Optimization of Extraction Conditions for the 6-Shogaol-rich Extract from Ginger (Zingiber officinale Roscoe)
por: Ok, Seon, et al.
Publicado: (2012)

Generation and differentiation of chemically derived hepatic progenitors from mouse primary hepatocytes
por: Kim, Yohan, et al.
Publicado: (2021)

Long-Surviving Patients with Recurrent GIST after Receiving Cytoreductive Surgery with Imatinib Therapy
por: Choi, Won Hyuk, et al.
Publicado: (2009)

Impact of High-Dose Irradiation on Human iPSC-Derived Cardiomyocytes Using Multi-Electrode Arrays: Implications for the Antiarrhythmic Effects of Cardiac Radioablation
por: Kim, Jae Sik, et al.
Publicado: (2021)

Amelioration of High Fructose-Induced Cardiac Hypertrophy by Naringin
por: Park, Jung Hyun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_7kiut1a87vc0idft81q1h2nasv