Inhibition of PCSK9 does not improve lipopolysaccharide-induced mortality in mice

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that targets LDL receptors (LDLRs) for degradation in liver. Blocking the interaction of PCSK9 with the LDLR potently reduces plasma LDL cholesterol levels and cardiovascular events. Recently, it has been suggested that inhi...

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Detalles Bibliográficos
Autores principales: Berger, Jean-Mathieu, Loza Valdes, Angel, Gromada, Jesper, Anderson, Norma, Horton, Jay D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538287/
https://www.ncbi.nlm.nih.gov/pubmed/28600283
http://dx.doi.org/10.1194/jlr.M076844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538287/
https://www.ncbi.nlm.nih.gov/pubmed/28600283
http://dx.doi.org/10.1194/jlr.M076844

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