Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration

γ‐Secretases are a family of intramembrane cleaving aspartyl proteases and important drug targets in Alzheimer's disease. Here, we generated mice deficient for all γ‐secretases in the pyramidal neurons of the postnatal forebrain by deleting the three anterior pharynx defective 1 (Aph1) subunits...

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Detalles Bibliográficos
Autores principales: Acx, Hermien, Serneels, Lutgarde, Radaelli, Enrico, Muyldermans, Serge, Vincke, Cécile, Pepermans, Elise, Müller, Ulrike, Chávez‐Gutiérrez, Lucía, De Strooper, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538297/
https://www.ncbi.nlm.nih.gov/pubmed/28588032
http://dx.doi.org/10.15252/emmm.201707561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538297/
https://www.ncbi.nlm.nih.gov/pubmed/28588032
http://dx.doi.org/10.15252/emmm.201707561

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