Oncolytic adenovirus expressing bispecific antibody targets T‐cell cytotoxicity in cancer biopsies

Oncolytic viruses exploit the cancer cell phenotype to complete their lytic life cycle, releasing progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group B adenovirus EnAdenotucirev (EnAd) to express a bispecific single‐chain antibody, secreted from infected tumo...

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Detalles Bibliográficos
Autores principales: Freedman, Joshua D, Hagel, Joachim, Scott, Eleanor M, Psallidas, Ioannis, Gupta, Avinash, Spiers, Laura, Miller, Paul, Kanellakis, Nikolaos, Ashfield, Rebecca, Fisher, Kerry D, Duffy, Margaret R, Seymour, Leonard W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538299/
https://www.ncbi.nlm.nih.gov/pubmed/28634161
http://dx.doi.org/10.15252/emmm.201707567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538299/
https://www.ncbi.nlm.nih.gov/pubmed/28634161
http://dx.doi.org/10.15252/emmm.201707567

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