Pharmacology of Thiopurine Therapy in Inflammatory Bowel Disease and Complete Blood Cell Count Outcomes: A 5-Year Database Study

BACKGROUND: Thiopurines are the prerequisite for immunomodulation in inflammatory bowel disease (IBD) therapy. When administered in high (oncological) dose, thiopurine metabolites act as purine antagonists, causing DNA-strand breakage and myelotoxicity. In lower IBD dosages, the mode of action is pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Meijer, Berrie, Wilhelm, Abraham J., Mulder, Chris J. J., Bouma, Gerd, van Bodegraven, Adriaan A., de Boer, Nanne K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Therapeutic Drug Monitoring 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538301/
https://www.ncbi.nlm.nih.gov/pubmed/28489727
http://dx.doi.org/10.1097/FTD.0000000000000414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538301/
https://www.ncbi.nlm.nih.gov/pubmed/28489727
http://dx.doi.org/10.1097/FTD.0000000000000414

Ejemplares similares