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Phenotypic diversity drives paracrine drug tolerance

Considerable clinical successes have been achieved in cancer treatment since the introduction of targeted therapies. However, almost inevitably tumors develop therapy resistance, which limits durable clinical responses. Tumors are often heterogeneous, and as a result, therapy‐resistant cells are pre...

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Detalles Bibliográficos
Autores principales: Kuilman, Thomas, Peeper, Daniel S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538330/
https://www.ncbi.nlm.nih.gov/pubmed/28694322
http://dx.doi.org/10.15252/emmm.201707956