Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates

Mitotic duration is determined by activation of the anaphase-promoting complex/cyclosome (APC/C) bound to its coactivator, Cdc20. Kinetochores, the microtubule-interacting machines on chromosomes, restrain mitotic exit when not attached to spindle microtubules by generating a Cdc20-containing comple...

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Detalles Bibliográficos
Autores principales: Kim, Taekyung, Lara-Gonzalez, Pablo, Prevo, Bram, Meitinger, Franz, Cheerambathur, Dhanya K., Oegema, Karen, Desai, Arshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538432/
https://www.ncbi.nlm.nih.gov/pubmed/28698300
http://dx.doi.org/10.1101/gad.302067.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538432/
https://www.ncbi.nlm.nih.gov/pubmed/28698300
http://dx.doi.org/10.1101/gad.302067.117

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