PRKCI promotes immune suppression in ovarian cancer

A key feature of high-grade serous ovarian carcinoma (HGSOC) is frequent amplification of the 3q26 locus harboring PRKC-ι (PRKCI). Here, we show that PRKCI is also expressed in early fallopian tube lesions, called serous tubal intraepithelial carcinoma. Transgenic mouse studies establish PRKCI as an...

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Detalles Bibliográficos
Autores principales: Sarkar, Sharmistha, Bristow, Christopher A., Dey, Prasenjit, Rai, Kunal, Perets, Ruth, Ramirez-Cardenas, Alejandra, Malasi, Shruti, Huang-Hobbs, Emmet, Haemmerle, Monika, Wu, Sherry Y., McGuire, Michael, Protopopov, Alexei, Jiang, Shan, Liu, Joyce F., Hirsch, Michelle S., Chang, Qing, Lazar, Alexander J., Sood, Anil K., Drapkin, Ronny, DePinho, Ronald, Draetta, Giulio, Chin, Lynda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538434/
https://www.ncbi.nlm.nih.gov/pubmed/28698296
http://dx.doi.org/10.1101/gad.296640.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538434/
https://www.ncbi.nlm.nih.gov/pubmed/28698296
http://dx.doi.org/10.1101/gad.296640.117

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