Discovery of Novel Allopurinol Derivatives with Anticancer Activity and Attenuated Xanthine Oxidase Inhibition

A series of pyrazolo[3,4-d]pyrimidine derivatives related to allopurinol has been synthesized and evaluated for its cytotoxicity against a panel of three cancer cell lines as well as its xanthine oxidase (XOD) inhibitory activities. Among them, compound 4 showed potent cytotoxicity with IC(50) value...

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Detalles Bibliográficos
Autores principales: Li, Yong, Cao, Ting-Ting, Guo, Shanchun, Zhong, Qiu, Li, Cai-Hu, Li, Ying, Dong, Lin, Zheng, Shilong, Wang, Guangdi, Yin, Shu-Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538589/
https://www.ncbi.nlm.nih.gov/pubmed/27331805
http://dx.doi.org/10.3390/molecules21060771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538589/
https://www.ncbi.nlm.nih.gov/pubmed/27331805
http://dx.doi.org/10.3390/molecules21060771

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