Synthesis of novel coumarin nucleus-based DPA drug-like molecular entity: In vitro DNA/Cu(II) binding, DNA cleavage and pro-oxidant mechanism for anticancer action

Despite substantial research on cancer therapeutics, systemic toxicity and drug-resistance limits the clinical application of many drugs like cisplatin. Therefore, new chemotherapeutic strategies against different malignancies are needed. Targeted cancer therapy is a new paradigm for cancer therapeu...

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Detalles Bibliográficos
Autores principales: Khan, Saman, Malla, Ali Mohammed, Zafar, Atif, Naseem, Imrana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538679/
https://www.ncbi.nlm.nih.gov/pubmed/28763458
http://dx.doi.org/10.1371/journal.pone.0181783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538679/
https://www.ncbi.nlm.nih.gov/pubmed/28763458
http://dx.doi.org/10.1371/journal.pone.0181783

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