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Single stranded adeno-associated virus achieves efficient gene transfer to anterior segment in the mouse eye

Adeno-associated viruses (AAVs) are used extensively as a gene delivery vehicle for retinal gene therapy, yet its ability to target the anterior segment of the eye, critical to unlocking therapeutic opportunities, is less characterized. Previously, self-complimentary (sc) AAV was shown to be necessa...

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Detalles Bibliográficos
Autores principales: Wang, Li, Xiao, Ru, Andres-Mateos, Eva, Vandenberghe, Luk H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538712/
https://www.ncbi.nlm.nih.gov/pubmed/28763501
http://dx.doi.org/10.1371/journal.pone.0182473