Defining the target and the effect of imatinib on the filarial c-Abl homologue

BACKGROUND: Previously we demonstrated the micro- and macrofilaricidal properties of imatinib in vitro. Here we use electron and multiphoton microscopy to define the target of imatinib in the adult and microfilarial stages of Brugia malayi and assess the effects of pharmacologically relevant levels...

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Detalles Bibliográficos
Autores principales: O’Connell, Elise M., Kamenyeva, Olena, Lustigman, Sara, Bell, Aaron, Nutman, Thomas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538754/
https://www.ncbi.nlm.nih.gov/pubmed/28727765
http://dx.doi.org/10.1371/journal.pntd.0005690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538754/
https://www.ncbi.nlm.nih.gov/pubmed/28727765
http://dx.doi.org/10.1371/journal.pntd.0005690

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