Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

Recent data have expanded our understanding of Notch signalling by identifying a C2 domain at the N‐terminus of Notch ligands, which has both lipid‐ and receptor‐binding properties. We present novel structures of human ligands Jagged2 and Delta‐like4 and human Notch2, together with functional assays...

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Detalles Bibliográficos
Autores principales: Suckling, Richard J, Korona, Boguslawa, Whiteman, Pat, Chillakuri, Chandramouli, Holt, Laurie, Handford, Penny A, Lea, Susan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538765/
https://www.ncbi.nlm.nih.gov/pubmed/28572448
http://dx.doi.org/10.15252/embj.201796632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538765/
https://www.ncbi.nlm.nih.gov/pubmed/28572448
http://dx.doi.org/10.15252/embj.201796632

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