p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling

Cellular senescence is a permanent state of cell cycle arrest that protects the organism from tumorigenesis and regulates tissue integrity upon damage and during tissue remodeling. However, accumulation of senescent cells in tissues during aging contributes to age‐related pathologies. A deeper under...

Descripción completa

Detalles Bibliográficos
Autores principales: Yosef, Reut, Pilpel, Noam, Papismadov, Nurit, Gal, Hilah, Ovadya, Yossi, Vadai, Ezra, Miller, Stav, Porat, Ziv, Ben‐Dor, Shifra, Krizhanovsky, Valery
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538795/
https://www.ncbi.nlm.nih.gov/pubmed/28607003
http://dx.doi.org/10.15252/embj.201695553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538795/
https://www.ncbi.nlm.nih.gov/pubmed/28607003
http://dx.doi.org/10.15252/embj.201695553

Ejemplares similares