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p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling
Cellular senescence is a permanent state of cell cycle arrest that protects the organism from tumorigenesis and regulates tissue integrity upon damage and during tissue remodeling. However, accumulation of senescent cells in tissues during aging contributes to age‐related pathologies. A deeper under...
Autores principales: | Yosef, Reut, Pilpel, Noam, Papismadov, Nurit, Gal, Hilah, Ovadya, Yossi, Vadai, Ezra, Miller, Stav, Porat, Ziv, Ben‐Dor, Shifra, Krizhanovsky, Valery |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538795/ https://www.ncbi.nlm.nih.gov/pubmed/28607003 http://dx.doi.org/10.15252/embj.201695553 |
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