Exosomes Facilitate Therapeutic Targeting of Oncogenic Kras in Pancreatic Cancer

The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes, extracellular vesicles generated by all cells, are naturally present in the blood. Here we demonstrate that enhanced retention of exosomes in circulation, compared to lipos...

Descripción completa

Detalles Bibliográficos
Autores principales: Kamerkar, Sushrut, LeBleu, Valerie S., Sugimoto, Hikaru, Yang, Sujuan, Ruivo, Carolina F., Melo, Sonia A., Lee, J. Jack, Kalluri, Raghu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538883/
https://www.ncbi.nlm.nih.gov/pubmed/28607485
http://dx.doi.org/10.1038/nature22341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538883/
https://www.ncbi.nlm.nih.gov/pubmed/28607485
http://dx.doi.org/10.1038/nature22341

Ejemplares similares