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Exosomes Facilitate Therapeutic Targeting of Oncogenic Kras in Pancreatic Cancer

The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes, extracellular vesicles generated by all cells, are naturally present in the blood. Here we demonstrate that enhanced retention of exosomes in circulation, compared to lipos...

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Detalles Bibliográficos
Autores principales:	Kamerkar, Sushrut, LeBleu, Valerie S., Sugimoto, Hikaru, Yang, Sujuan, Ruivo, Carolina F., Melo, Sonia A., Lee, J. Jack, Kalluri, Raghu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538883/ https://www.ncbi.nlm.nih.gov/pubmed/28607485 http://dx.doi.org/10.1038/nature22341

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