Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development

Constitutive depletion of p21-activated kinase 4 (PAK4) in the mouse causes embryonic lethality associated with heart and brain defects. Given that conventional gene depletion of PAK1 or PAK3 caused functional deficits in the mouse pancreas, while gene depletion of PAK5 or PAK6 did not, we asked if...

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Detalles Bibliográficos
Autores principales: Zhao, Miao, Rabieifar, Parisa, Costa, Tânia D. F., Zhuang, Ting, Minden, Audrey, Löhr, Matthias, Heuchel, Rainer, Strömblad, Staffan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539201/
https://www.ncbi.nlm.nih.gov/pubmed/28765528
http://dx.doi.org/10.1038/s41598-017-07322-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539201/
https://www.ncbi.nlm.nih.gov/pubmed/28765528
http://dx.doi.org/10.1038/s41598-017-07322-5

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