Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model

The catabolism of hyaluronan in articular cartilage remains unclear. The aims of this study were to investigate the effects of hyaluronidase 2 (Hyal2) knockdown in articular cartilage on the development of osteoarthritis (OA) using genetic manipulated mice. Destabilization of the medial meniscus (DM...

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Detalles Bibliográficos
Autores principales: Higuchi, Yoshitoshi, Nishida, Yoshihiro, Kozawa, Eiji, Zhuo, Lisheng, Arai, Eisuke, Hamada, Shunsuke, Morita, Daigo, Ikuta, Kunihiro, Kimata, Koji, Ushida, Takahiro, Ishiguro, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539311/
https://www.ncbi.nlm.nih.gov/pubmed/28765635
http://dx.doi.org/10.1038/s41598-017-07376-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539311/
https://www.ncbi.nlm.nih.gov/pubmed/28765635
http://dx.doi.org/10.1038/s41598-017-07376-5

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