The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1

iNKT cells are a unique lineage of T cells that recognize glycolipid presented by CD1d. In the thymus, they differentiate into iNKT1, iNKT2 and iNKT17 effector subsets, characterized by preferential expression of Tbet, Gata3 and ROR-γt and production of IFN-γ, IL-4 and IL-17, respectively. We demons...

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Detalles Bibliográficos
Autores principales: Thapa, Puspa, Manso, Bryce, Chung, Ji Young, Romera Arocha, Sinibaldo, Xue, Hai-Hui, Angelo, Derek B. Sant’, Shapiro, Virginia Smith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539328/
https://www.ncbi.nlm.nih.gov/pubmed/28765611
http://dx.doi.org/10.1038/s41598-017-07365-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539328/
https://www.ncbi.nlm.nih.gov/pubmed/28765611
http://dx.doi.org/10.1038/s41598-017-07365-8

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