Cargando…

The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1

iNKT cells are a unique lineage of T cells that recognize glycolipid presented by CD1d. In the thymus, they differentiate into iNKT1, iNKT2 and iNKT17 effector subsets, characterized by preferential expression of Tbet, Gata3 and ROR-γt and production of IFN-γ, IL-4 and IL-17, respectively. We demons...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thapa, Puspa, Manso, Bryce, Chung, Ji Young, Romera Arocha, Sinibaldo, Xue, Hai-Hui, Angelo, Derek B. Sant’, Shapiro, Virginia Smith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539328/ https://www.ncbi.nlm.nih.gov/pubmed/28765611 http://dx.doi.org/10.1038/s41598-017-07365-8

Ejemplares similares

Histone deacetylase 3 is required for iNKT cell development
por: Thapa, Puspa, et al.
Publicado: (2017)

The transcriptional repressor NKAP is required for the development of iNKT cells
por: Thapa, Puspa, et al.
Publicado: (2013)

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients
por: Venken, Koen, et al.
Publicado: (2019)

CD8(+) T-cell immunity orchestrated by iNKT cells
por: Qin, Yingyu, et al.
Publicado: (2023)

iNKT cell development is orchestrated by different branches of TGF-β signaling
por: Doisne, Jean-Marc, et al.
Publicado: (2009)

β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation
por: Berga-Bolaños, Rosa, et al.
Publicado: (2015)

NKT10 cells: a novel iNKT cell subset
por: Wingender, Gerhard, et al.
Publicado: (2015)

iNKT and MAIT Cell Alterations in Diabetes
por: Magalhaes, Isabelle, et al.
Publicado: (2015)

The Role of Autophagy in iNKT Cell Development
por: Yang, Guan, et al.
Publicado: (2018)

Recent advances in iNKT cell development
por: Hogquist, Kristin, et al.
Publicado: (2020)

Graphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model
por: Lee, Sung Won, et al.
Publicado: (2018)

Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy
por: Aoki, Takahiro, et al.
Publicado: (2023)

The iNKT Cell–Macrophage Axis in Homeostasis and Disease
por: Cruz, Mariana S., et al.
Publicado: (2022)

BATF regulates the development and function of IL-17 producing iNKT cells
por: Jordan-Williams, Kimberly L, et al.
Publicado: (2013)

Diacylglycerol Kinase Zeta Positively Controls the Development of iNKT-17 Cells
por: Wu, Jinhong, et al.
Publicado: (2013)

NNKTT120, an anti-iNKT cell monoclonal antibody, produces rapid and sustained iNKT cell depletion in adults with sickle cell disease
por: Field, Joshua J., et al.
Publicado: (2017)

The Ras/MAPK Pathway Is Required for Generation of iNKT Cells
por: Hu, Taishan, et al.
Publicado: (2011)

Developmental Dynamics of Post-Selection Thymic DN iNKT
por: Yassai, Maryam, et al.
Publicado: (2012)

Enhancing Neuroblastoma Immunotherapies by Engaging iNKT and NK Cells
por: McNerney, Kevin O., et al.
Publicado: (2020)

Alterations of the iNKT cell compartment in brain-injured patients
por: Patinec, Allan, et al.
Publicado: (2019)

The impact of stress on the transcriptomic signature of iNKT1 cells
por: Papadogianni, Georgia, et al.
Publicado: (2021)

Modulation of Tregs and iNKT by Fingolimod in Multiple Sclerosis Patients
por: Ferraro, Diana, et al.
Publicado: (2021)

Human iNKT Cells Modulate Macrophage Survival and Phenotype
por: Loureiro, J. Pedro, et al.
Publicado: (2022)

New insights into iNKT cells and their roles in liver diseases
por: Gu, Xinyu, et al.
Publicado: (2022)

Regulatory iNKT cells lack PLZF expression and control T(reg) cell and macrophage homeostasis in adipose tissue
por: Lynch, Lydia, et al.
Publicado: (2014)

Potential Role of IL-17-Producing iNKT Cells in Type 1 Diabetes
por: Li, Shamin, et al.
Publicado: (2014)

CD138 expression is a molecular signature but not a developmental requirement for RORγt(+) NKT17 cells
por: Luo, Shunqun, et al.
Publicado: (2021)

An Essential Role for the Transcription Factor Runx1 in T Cell Maturation
por: Hsu, Fan-Chi, et al.
Publicado: (2016)

Intracellular IL-4 and IFN-γ expression in iNKT cells from patients with chronic lymphocytic leukemia
por: Bojarska-Junak, Agnieszka, et al.
Publicado: (2018)

A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease
por: Ren, Yue, et al.
Publicado: (2017)

Thymic stromal lymphopoietin production in DN32.D3 invariant natural killer T (iNKT) cell line and primary mouse liver iNKT cells
por: Choi, Jun-Pyo, et al.
Publicado: (2021)

Single-cell analysis reveals differences among iNKT cells colonizing peripheral organs and identifies Klf2 as a key gene for iNKT emigration
por: Wang, Jie, et al.
Publicado: (2022)

The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells
por: Yasuoka, Toshiaki, et al.
Publicado: (2016)

miR-150 regulates the development of NK and iNKT cells
por: Bezman, Natalie A., et al.
Publicado: (2011)

iNKT Cell Production of GM-CSF Controls Mycobacterium tuberculosis
por: Rothchild, Alissa C., et al.
Publicado: (2014)

An In Silico Approach for Modelling T-Helper Polarizing iNKT Cell Agonists
por: De Spiegeleer, Anton, et al.
Publicado: (2014)

Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment
por: Lawrenczyk, Agnieszka, et al.
Publicado: (2014)

iNKT Cells and Their Potential Lipid Ligands during Viral Infection
por: Opasawatchai, Anunya, et al.
Publicado: (2015)

The Pathophysiological Relevance of the iNKT Cell/Mononuclear Phagocyte Crosstalk in Tissues
por: Cortesi, Filippo, et al.
Publicado: (2018)

iNKT: A new avenue for CAR-based cancer immunotherapy
por: Liu, Yilin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pghbamlr3rp7j20veumvisa227