Early detection of the aflatoxin B(1) mutational fingerprint: A diagnostic tool for liver cancer

Using duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B(1) in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnostic power of this spectrum is then demonstrated...

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Detalles Bibliográficos
Autores principales: Fedeles, Bogdan I., Chawanthayatham, Supawadee, Croy, Robert G., Wogan, Gerald N., Essigmann, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540215/
https://www.ncbi.nlm.nih.gov/pubmed/28868344
http://dx.doi.org/10.1080/23723556.2017.1329693
Descripción
Sumario:Using duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B(1) in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnostic power of this spectrum is then demonstrated by accurately identifying, among the sequenced human liver tumors, the subset of cancers associated with aflatoxin B(1) exposure.

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